Premature ovarian failure affects 1-2% of women and can have far-reaching clinical and psychological effects and the incidence is expected to increase because of improved patient survival following gonadotoxic cancer treatment. Although around twenty live births have been achieved to date in women receiving autografts of ovarian cortex frozen by controlled rate slow freezing, the application of the treatment is a bit limited by the ~30% rates of primordial follicle survival.
Researchers at the Universities of Nottingham, Prof Bruce Campbell, and Leeds, Prof Helen Picton, are examining ways to make cryopreservation of ovarian tissue more efficient. They are examining the hypothesis that sub-lethal cryodamage and cyto-toxicity is responsible for the higher rate of follicle loss and have been examining whether the novel Liquidus Tracking methodology, developed by Planer, could be usefully applied. The controlled vitrification associated with this technique eliminates both ice crystallisation and the cytotoxic effects of cryoprotectant at higher temperatures.
The results of one such study are to be presented at the European Society of Human Reproduction and Embryology (ESHRE) in London in July. The lead author of this publication, Feda Aljaser (pictured), supported by King Saud University, will report the results of a comparison between conventional slow freezing and Liquidus Tracking for the cryopreservation of both sheep ovarian cortical tissue and whole ovaries, in terms of post-thaw tissue damage and follicle survival in vitro. Encouragingly, the results of this comparison indicate that LT may also be used to successfully freeze ovarian cortical patches and whole ovaries, as this methodology resulted in similar levels of tissue damage and follicle survival as slow freezing. Importantly, rapid vitrification of ovarian cortical patches resulted in significantly higher levels of tissue damage and poor follicle survival.
Monitor CO2 and temperature and LN2 and more !
Our new solution gives you a secure and scalable data solution for the whole lab environment.
You can monitor temperature, carbon dioxide, liquid nitrogen levels and more, all with a minimal IT footprint and a minimal IT support overhead.
ReAssure lets you access your data anywhere via a PC, a tablet or phone. It has an intuitive and simple user interface and a range of unique sensor options.
In addition to a range of traditional sensor options, with ReAssure you can also include unique features: a new per chamber CO2 monitoring for Benchtop Incubators like our BT 37; a brand new fluorescent based pH sensor; connection to controllers, like the TEC 3000 or new Cryofill unit.
Using the compliant storage option in ReAssure helps take the pain out of those visits from the auditor; it reports all alarm events, with any associated comments you want to put in. You can also graph multiple parameters over time which makes compliance easier but it also helps your job: for example it makes it easier to predict potential failure events all via simple "at the touch of a button" controls.
So - more time for real IVF and less time worrying!
Are you feeling lucky? You've a good chance of winning an iPad mini in our quick competition to introduce our new monitoring system.
This new monitoring and alarm solution, ReAssure, is made for large and small labs. On the iPad Mini - which by the way is one of the many devices one can view the monitoring data on - you can for example show:
To find out more, visit http://reassuredemo.planer.co.uk using the log in details below or get in touch!
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And for your chance to win that iPad Mini, please click on the link below to answer the few simple questions! www.planer.com/ipad-mini-quiz
You can visit us at the upcoming ESHRE conference in London (7th-10th July) at Booth B114 and the winner will be announced after the show. Good Luck!
Earlier this year we helped in the donation of one of our bench-top BT37 incubators to Monash University for their 'Master of Clinical Embryology' course. Designed for embryo growth, incubators such as these have been responsible for greatly improving IVF results due to their stability and use of reduced oxygen, replicating in vivo conditions. The twelve month intensive course programme aims to provide students with practical experience of leading edge equipment such as this, along with all the essential knowledge and practical skills to contribute competently to any human infertility clinical service. Both theoretical and practical in approach the course also takes into account the contexts of international regulations and ethical considerations applying in human IVF, together with allied QA procedures, guidelines, protocols and regulations. As well as attending lectures and self-directed study, students are required to undertake practical skills training and also a minor research project, as research-related tasks contribute to the overall assessment.